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Denali Therapeutics Inc. (Nasdaq: DNLI) is a biotechnology company pioneering a new class of biotherapeutics designed to cross the blood-brain barrier using our proprietary TransportVehicle^TM platform. With a clinically validated delivery platform and a growing portfolio of therapeutic candidates across all stages of development, we are advancing toward our goal of delivering effective medicines to transform the lives of people living with neurodegenerative, lysosomal and other serious diseases.

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Denali Therapeutics Inc. was incorporated in Delaware in October 2013

Denali is headquartered in South San Francisco, CA.

Denali's fiscal year ends December 31st

Ernst & Young LLP is Denali's independent registered public accounting firm

Denali is traded on the NASDAQ Global Select Stock Market under the ticker symbol "DNLI"

Denali initial public offering occurred on December 8, 2017

24823R 105

Broadridge Financial Solutions

5 Dakota Drive, Suite 300,
Lake Success, NY 11042
+1 800 353 0103

https://www.broadridge.com/contact

Electronic copies of our Annual Report and other periodic reports are available on this website. If you would like to request paper copies of the Annual Report or other periodic reports, send your request in writing to:

Denali Therapeutics Inc.

Attn: Corporate Secretary

151 Oyster Point Blvd

South San Francisco, CA 94080

Please contact InvestorRelations@dnli.com for additional questions or inquiries.

Investors & News

Press Releases

Denali Therapeutics Announces U.S. FDA Approval of AVLAYAH™ (tividenofusp alfa-eknm) for Treatment of Hunter Syndrome (MPS II)

Denali Therapeutics Reports Fourth Quarter and Full Year 2025 Financial Results and Business Highlights

Denali Therapeutics Presents Enzyme TransportVehicle™ Progress Across Three Clinical Programs for Treatment of Lysosomal Storage Disorders at 2026 WORLDSymposium™

Denali Therapeutics To Host Webcast Highlighting Presentations on Enzyme TransportVehicle™ Programs at the 2026 WORLDSymposium™

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Corporate Presentation

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Investors & News

Press Releases

Denali Therapeutics Announces U.S. FDA Approval of AVLAYAH™ (tividenofusp alfa-eknm) for Treatment of Hunter Syndrome (MPS II)

Denali Therapeutics Reports Fourth Quarter and Full Year 2025 Financial Results and Business Highlights

Denali Therapeutics Presents Enzyme TransportVehicle™ Progress Across Three Clinical Programs for Treatment of Lysosomal Storage Disorders at 2026 WORLDSymposium™

Denali Therapeutics To Host Webcast Highlighting Presentations on Enzyme TransportVehicle™ Programs at the 2026 WORLDSymposium™

Recent Events

Corporate Presentation

FAQs

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