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SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
Under the Securities Exchange Act of 1934
Denali Therapeutics Inc
(Amendment No.5)
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(Name of Issuer)
Common Stock
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(Title of Class of Securities)
24823R105
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(CUSIP Number)
30th December 2022
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(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:
[X] Rule 13d-1(b)
[ ] Rule 13d-1(c)
[ ] Rule 13d-1(d)
*The remainder of this cover page shall be filled out for a reporting
persons initial filing on this form with respect to the subject class
of securities, and for any subsequent amendment containing information
which would alter the disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not
be deemed to be filed for the purpose of Section 18 of the Securities
Exchange Act of 1934 (Act) or otherwise subject to the liabilities of
that section of the Act but shall be subject to all other provisions of
the Act (however, see the Notes).
Persons who respond to the collection of information contained in this
form are not required to respond unless the form displays a currently
valid OMB control number.
SEC 1745 (3-06)
CUSIP No. 24823R105
_______________________________________________________________________
1. Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).
Baillie Gifford & Co (Scottish partnership)
_______________________________________________________________________
2. Check the Appropriate Box if a Member of a Group (See Instructions)
(a)....................................................................
(b)....................................................................
_______________________________________________________________________
3. SEC Use Only
_______________________________________________________________________
4. Citizenship or Place of Organization
SCOTLAND UK
_______________________________________________________________________
Number of 5. Sole Voting Power 14,943,665
Shares Bene ______________________________________________________
ficially by 6. Shared Voting Power 0
Owned by Each ______________________________________________________
Reporting 7. Sole Dispositive Power 15,119,474
Person With: ______________________________________________________
8. Shared Dispositive Power 0
_______________________________________________________________________
9. Aggregate Amount Beneficially Owned by Each Reporting Person
15,119,474
10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares
(See Instructions)
11. Percent of Class Represented by Amount in Row (9) 11.13%
_______________________________________________________________________
12. Type of Reporting Person (See Instructions) IA
_______________________________________________________________________
Item 1.
(a) Name of Issuer Denali Therapeutics Inc
(b) Address of Issuers Principal Executive Offices
161 Oyster Point Blvd
South San Francisco
CA 94080
Item 2.
(a) Name of Person Filing Baillie Gifford & Co
(b) Address of Principal Business Office or, if none, Residence
Calton Square
1 Greenside Row
Edinburgh EH1 3AN
Scotland
UK
(c) Citizenship Scotland UK
(d) Title of Class of Securities Common Stock
(e) CUSIP Number 24823R105
Item 3. If this statement is filed pursuant to rule 240.13d-1(b) or
240.13d-2(b) or (c), check whether the person filing is a:
(a) Broker or dealer registered under section 15 of the Act
(15 U.S.C. 78o).
(b) Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).
(c) Insurance company as defined in section 3(a)(19) of the Act
(15 U.S.C. 78c).
(d) Investment company registered under section 8 of the Investment
Company Act of 1940 (15 U.S.C 80a-8).
(e) An investment adviser in accordance with rule 240.13d-
1(b)(1)(ii)(E)
(f) An employee benefit plan or endowment fund in accordance with
240.13d-1(b)(1)(ii)(F)
(g) A parent holding company or control person in accordance with
rule 240.13d-1(b) (1)(ii)(G)
(h) A savings associations as defined in Section 3(b) of the Federal
Deposit Insurance Act (12 U.S.C. 1813)
(j) X A non-U.S. institution in accordance with 240.13d-1(b)(1)(ii)(J);
(k)
Group, in accordance with 240.13d-1(b)(1)(ii)(K). If filing as a non-U.S.
institution in accordance with 240.13d-1(b)(1)(ii)(J),
please specify the type of institution: ____
Item 4. Ownership.
Provide the following information regarding the aggregate number and
Percentage of the class of securities of the issuer identified in Item 1.
(a) Amount beneficially owned: see row (9) on page 2.
(b) Percent of Class: see row (11) on page 2.
(c) Number of shares as to which the person has:
(i) Sole power to vote or to direct the vote
See row (5) on page 2.
(ii) Shared power to vote or to direct the vote
See row (6) on page 2
(iii) Sole power to dispose or to direct the disposition of
See row (7) on page 2
(iv) Shared power to dispose or to direct the disposition of
See row (8) on page 2
Item 5. Ownership of Five Percent or Less of a Class
If this statement is being filed to report the fact that as of the date
hereof the reporting person has ceased to be the beneficial owner of
more than five percent of the class of securities, check the following.
[ ]
Not applicable.
Item 6. Ownership of More than Five Percent on Behalf of Another Person.
Securities reported on this Schedule 13G as being beneficially owned by
Baillie Gifford & Co. are held by Baillie Gifford & Co. and/or one or
more of its investment adviser subsidiaries, which may include Baillie
Gifford Overseas Limited, on behalf of investment advisory clients, which
may include investment companies registered under the Investment Company
Act, employee benefit plans, pension funds or other institutional
clients. Securities representing more than 5% of the class are held on behalf
of Scottish Mortgage Investment Trust PLC, a closed-ended investment trust
which is managed by Baillie Gifford & Co Limited, a wholly owned subsidiary of
Baillie Gifford & Co.
[x]
Item 7. Identification and Classification of the Subsidiary Which
Acquired the Security Being Reported on By the Parent Holding Company
Not applicable.
Item 8. Identification and Classification of Members of the Group
Not applicable.
Item 9. Notice of Dissolution of Group
Not applicable.
Item 10. Certification
By signing below I certify that, to the best of my knowledge and
belief:
- the securities referred to above were acquired and are held in
the ordinary course of business and were not acquired and are not held
for the purpose of or with the effect of changing or influencing the
control of the issuer of the securities and were not acquired and are
not held in connection with or as a participant in any transaction
having that purpose or effect.
- the foreign regulatory scheme applicable to investment advisers is
substantially comparable to the functionally equivalent U.S.
institution(s).
I also undertake to furnish the Commission staff, upon request,
information that would otherwise be disclosed in a Schedule 13D.
SIGNATURE
After reasonable enquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true,
complete and correct
20 January 2023
________________________________
Date
Grant Meikle
_______________________________________
Signature
Grant Meikle
Compliance Manager
_______________________________________
Name/Title
The original statement shall be signed by each person on
whose behalf the statement is filed or his authorized representative.
If the statement is signed on behalf of a person by his authorized
representative other than an executive officer or general partner of
the filing person, evidence of the representatives authority to sign
on behalf of such person shall be filed with the statement, provided,
however, that a power of attorney for this purpose which is already on
file with the Commission may be incorporated by reference. The name and
any title of each person who signs the statement shall be typed or
printed beneath his signature.
NOTE: Schedules filed in paper format shall include a signed original
and five copies of the schedule,including all exhibits. See rule 240.13d-
7 for other parties for whom copies are to be sent.
Attention: Intentional misstatements or omissions of fact constitute
Federal criminal violations (See 18 U.S.C. 1001)