Denali Therapeutics Inc.
|
(Name of Issuer)
|
|
Common Stock par value $0.01 per share
|
(Title of Class of Securities)
|
|
24823R105
|
(CUSIP Number)
|
|
December 31, 2019
|
(Date of Event Which Requires Filing of this Statement)
|
CUSIP No. 24823R105
|
13G
|
Page 2 of 12 Pages
|
1
|
NAMES OF REPORTING PERSONS
|
|
|
||
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
|
|
|
|||
ARCH Venture Fund VIII, L.P.
|
|
|
|||
|
|
||||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
|
||||
(a)☐
|
|||||
(b)☐
|
|
|
|||
3
|
SEC USE ONLY
|
|
|
||
|
|
|
|||
|
|
||||
4
|
CITIZENSHIP OR PLACE OF ORGANIZATION
|
|
|
||
Delaware
|
|
|
|||
|
|
||||
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
|
5
|
SOLE VOTING POWER
|
|
|
|
0
|
|
|
|||
|
|
||||
6
|
SHARED VOTING POWER
|
|
|
||
10,668,749
|
|
|
|||
|
|
||||
7
|
SOLE DISPOSITIVE POWER
|
|
|
||
0
|
|
|
|||
|
|
||||
8
|
SHARED DISPOSITIVE POWER
|
|
|
||
10,668,749
|
|
|
|||
|
|
||||
9
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
|
|
|
||
10,668,749
|
|
|
|||
|
|
||||
10
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
|
|
|
||
☐
|
|
|
|||
|
|
||||
11
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
|
|
|
||
11.1%
|
|
|
|||
|
|
||||
12
|
TYPE OF REPORTING PERSON*
|
|
|
||
PN
|
|
|
|||
|
|
CUSIP No. 24823R105
|
13G
|
Page 3 of 12 Pages
|
1
|
NAMES OF REPORTING PERSONS
|
|
|
||
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
|
|
|
|||
ARCH Venture Partners VIII, L.P.
|
|
|
|||
|
|
||||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
|
||||
(a)☐
|
|||||
(b)☐
|
|
|
|||
3
|
SEC USE ONLY
|
|
|
||
|
|
|
|||
|
|
||||
4
|
CITIZENSHIP OR PLACE OF ORGANIZATION
|
|
|
||
Delaware
|
|
|
|||
|
|
||||
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
|
5
|
SOLE VOTING POWER
|
|
|
|
0
|
|
|
|||
|
|
||||
6
|
SHARED VOTING POWER
|
|
|
||
10,668,749
|
|
|
|||
|
|
||||
7
|
SOLE DISPOSITIVE POWER
|
|
|
||
0
|
|
|
|||
|
|
||||
8
|
SHARED DISPOSITIVE POWER
|
|
|
||
10,668,749
|
|
|
|||
|
|
||||
9
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
|
|
|
||
10,668,749
|
|
|
|||
|
|
||||
10
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
|
|
|
||
☐
|
|
|
|||
|
|
||||
11
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
|
|
|
||
11.1%
|
|
|
|||
|
|
||||
12
|
TYPE OF REPORTING PERSON*
|
|
|
||
PN
|
|
|
|||
|
|
CUSIP No. 24823R105
|
13G
|
Page 4 of 12 Pages
|
1
|
NAMES OF REPORTING PERSONS
|
|
|
||
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
|
|
|
|||
ARCH Venture Partners VIII, LLC
|
|
|
|||
|
|
||||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
|
||||
(a)☐
|
|||||
(b)☐
|
|
|
|||
3
|
SEC USE ONLY
|
|
|
||
|
|
|
|||
|
|
||||
4
|
CITIZENSHIP OR PLACE OF ORGANIZATION
|
|
|
||
Delaware
|
|
|
|||
|
|
||||
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
|
5
|
SOLE VOTING POWER
|
|
|
|
0
|
|
|
|||
|
|
||||
6
|
SHARED VOTING POWER
|
|
|
||
10,668,749
|
|
|
|||
|
|
||||
7
|
SOLE DISPOSITIVE POWER
|
|
|
||
0
|
|
|
|||
|
|
||||
8
|
SHARED DISPOSITIVE POWER
|
|
|
||
10,668,749
|
|
|
|||
|
|
||||
9
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
|
|
|
||
10,668,749
|
|
|
|||
|
|
||||
10
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
|
|
|
||
☐
|
|
|
|||
|
|
||||
11
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
|
|
|
||
11.1%
|
|
|
|||
|
|
||||
12
|
TYPE OF REPORTING PERSON*
|
|
|
||
OO
|
|
|
|||
|
|
CUSIP No. 24823R105
|
13G
|
Page 5 of 12 Pages
|
1
|
NAMES OF REPORTING PERSONS
|
|
|
||
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
|
|
|
|||
Keith Crandell
|
|
|
|||
|
|
||||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
|
||||
(a)☐
|
|||||
(b)☐
|
|
|
|||
3
|
SEC USE ONLY
|
|
|
||
|
|
|
|||
|
|
||||
4
|
CITIZENSHIP OR PLACE OF ORGANIZATION
|
|
|
||
United States of America
|
|
|
|||
|
|
||||
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
|
5
|
SOLE VOTING POWER
|
|
|
|
2,030
|
|
|
|||
|
|
||||
6
|
SHARED VOTING POWER
|
|
|
||
10,668,749
|
|
|
|||
|
|
||||
7
|
SOLE DISPOSITIVE POWER
|
|
|
||
2,030
|
|
|
|||
|
|
||||
8
|
SHARED DISPOSITIVE POWER
|
|
|
||
10,668,749
|
|
|
|||
|
|
||||
9
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
|
|
|
||
10,670,779
|
|
|
|||
|
|
||||
10
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
|
|
|
||
☐
|
|
|
|||
|
|
||||
11
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
|
|
|
||
11.1%
|
|
|
|||
|
|
||||
12
|
TYPE OF REPORTING PERSON*
|
|
|
||
IN
|
|
|
|||
|
|
CUSIP No. 24823R105
|
13G
|
Page 6 of 12 Pages
|
1
|
NAMES OF REPORTING PERSONS
|
|
|
||
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
|
|
|
|||
Clinton Bybee
|
|
|
|||
|
|
||||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
|
||||
(a)☐
|
|||||
(b)☐
|
|
|
|||
3
|
SEC USE ONLY
|
|
|
||
|
|
|
|||
|
|
||||
4
|
CITIZENSHIP OR PLACE OF ORGANIZATION
|
|
|
||
United States of America
|
|
|
|||
|
|
||||
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
|
5
|
SOLE VOTING POWER
|
|
|
|
1,955
|
|
|
|||
|
|
||||
6
|
SHARED VOTING POWER
|
|
|
||
10,668,749
|
|
|
|||
|
|
||||
7
|
SOLE DISPOSITIVE POWER
|
|
|
||
1,955
|
|
|
|||
|
|
||||
8
|
SHARED DISPOSITIVE POWER
|
|
|
||
10,668,749
|
|
|
|||
|
|
||||
9
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
|
|
|
||
10,670,704
|
|
|
|||
|
|
||||
10
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
|
|
|
||
☐
|
|
|
|||
|
|
||||
11
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
|
|
|
||
11.1%
|
|
|
|||
|
|
||||
12
|
TYPE OF REPORTING PERSON*
|
|
|
||
IN
|
|
|
|||
|
|
CUSIP No. 24823R105
|
13G
|
Page 7 of 12 Pages
|
1
|
NAMES OF REPORTING PERSONS
|
|
|
||
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
|
|
|
|||
Robert Nelsen
|
|
|
|||
|
|
||||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
|
||||
(a)☐
|
|||||
(b)☐
|
|
|
|||
3
|
SEC USE ONLY
|
|
|
||
|
|
|
|||
|
|
||||
4
|
CITIZENSHIP OR PLACE OF ORGANIZATION
|
|
|
||
United States of America
|
|
|
|||
|
|
||||
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
|
5
|
SOLE VOTING POWER
|
|
|
|
29,860
|
|
|
|||
|
|
||||
6
|
SHARED VOTING POWER
|
|
|
||
10,668,749
|
|
|
|||
|
|
||||
7
|
SOLE DISPOSITIVE POWER
|
|
|
||
29,860
|
|
|
|||
|
|
||||
8
|
SHARED DISPOSITIVE POWER
|
|
|
||
10,668,749
|
|
|
|||
|
|
||||
9
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
|
|
|
||
10,698,609
|
|
|
|||
|
|
||||
10
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
|
|
|
||
☐
|
|
|
|||
|
|
||||
11
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
|
|
|
||
11.1%
|
|
|
|||
|
|
||||
12
|
TYPE OF REPORTING PERSON*
|
|
|
||
IN
|
|
|
|||
|
|
CUSIP No. 24823R105
|
13G
|
Page 8 of 12 Pages
|
Item 1(a). | Name of Issuer |
Item 1(b). | Address of Issuer's Principal Executive Offices |
Item 2(a). | Name of Person Filing |
Item 2(b). | Address of Principal Business Office or, if none, Residence |
Item 2(c). | Citizenship |
Item 2(d). | Title of Class of Securities |
Item 2(e). | CUSIP Number |
Item 3. |
If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b) or (c), Check Whether the Person Filing is a:
|
Item 4. | Ownership |
(a)
|
Amount beneficially owned:
|
(b)
|
Percent of class:
|
CUSIP No. 24823R105
|
13G
|
Page 9 of 12 Pages
|
(c)
|
Number of shares as to which such person has:
|
Item 5. | Ownership of Five Percent or Less of a Class |
Item 6. | Ownership of More Than Five Percent on Behalf of Another Person |
Item 7. |
Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company
|
Item 8. | Identification and Classification of Members of the Group |
Item 9. | Notice of Dissolution of Group |
Item 10.
|
Certification
|
CUSIP No. 24823R105
|
13G
|
Page 10 of 12 Pages
|
ARCH VENTURE FUND VIII, L.P.
|
|
By: ARCH Venture Partners VIII, L.P.
|
|
its General Partner |
By: ARCH Venture Partners VIII, LLC
|
|
its General Partner
|
By: *
|
|
Keith Crandell
|
|
Managing Director
|
ARCH VENTURE PARTNERS VIII, L.P.
|
|
By: ARCH Venture Partners VIII, LLC
|
|
its General Partner |
By: *
|
|
Keith Crandell
|
|
Managing Director |
ARCH VENTURE PARTNERS VIII, LLC
|
|
By: *
|
|
Keith Crandell | |
Managing Director |
*
|
|
Keith Crandell |
*
|
|
Robert Nelsen
|
*
|
|
Clinton Bybee
|
* By: /s/ Mark McDonnell
|
||
Mark McDonnell as
|
||
Attorney-in-Fact
|
CUSIP No. 24823R105
|
13G
|
Page 11 of 12 Pages
|
Dated: February 13, 2020
|
ARCH VENTURE FUND VIII, L.P.
|
By: ARCH Venture Partners VIII, L.P.
|
|
its General Partner |
By: ARCH Venture Partners VIII, LLC
|
|
its General Partner
|
By: *
|
|
Keith Crandell
|
|
Managing Director
|
ARCH VENTURE PARTNERS VIII, L.P.
|
|
By: ARCH Venture Partners VIII, LLC
|
|
its General Partner |
By: *
|
|
Keith Crandell
|
|
Managing Director |
ARCH VENTURE PARTNERS VIII, LLC
|
|
By: *
|
|
Keith Crandell | |
Managing Director |
*
|
|
Keith Crandell |
*
|
|
Robert Nelsen
|
*
|
|
Clinton Bybee
|
* By: /s/ Mark McDonnell
|
||
Mark McDonnell as
|
||
Attorney-in-Fact
|
CUSIP No. 24823R105
|
13G
|
Page 12 of 12 Pages
|
ARCH VENTURE FUND VIII, L.P.
|
|
By: ARCH Venture Partners VIII, L.P.
|
|
its General Partner |
By: ARCH Venture Partners VIII, LLC
|
|
its General Partner
|
By: /s/ Keith Crandell
|
|
Managing Director
|
ARCH VENTURE PARTNERS VIII, L.P.
|
|
By: ARCH Venture Partners VIII, LLC
|
|
its General Partner |
By: /s/ Keith Crandell
|
|
Managing Director |
ARCH VENTURE PARTNERS VIII, LLC
|
|
By: /s/ Keith Crandell
|
|
Managing Director |
/s/ Keith Crandell
|
|
Keith Crandell |
/s/ Robert Nelsen
|
|
Robert Nelsen
|
/s/ Clinton Bybee
|
|
Clinton Bybee
|
/s/ Kristina Burow
|
|
Kristina Burow
|
/s/ Paul Thurk
|
|
Paul Thurk
|